Games : why wont my skyrim load from the main menu

I am having problems with not even getting to play the game. I got the game for Christmas and i played it for a while and then stopped the next time i tried it i press play and choose my storage device then two seconds later it freezes completely. But if i play as a guest without saving i can start a new game. My sister is in a different place in the game and the same thing happens to her my dad hasnt even started and it happens with him if you press load. We all play on different storage devices and i have cleared cache multiple times i deleted all older saves and it still does the same thing. I was really enjoying the game so what do i do and i play on xbox 360 with a disk and DLC with hearthfire dragonborn and dawnguard